@article{shirvalkar.25,
    author = {Shirvalkar, P. and Rozell, C.J.},
    title = {Brain Biomarkers for Pain Sensitivity},
    journal = {JAMA Neurology},
    year = {2025},
    month = jan,
    abstract = {Identifying objective biomarkers that track individual pain severity has been dubbed “the holy grail” of pain neuroscience. While pain is among the most fundamental, ubiquitous, and adaptive experiences that can befall an organism, there is still a murky understanding of how pain is generated in the nervous system. Modern consensus on brain mechanisms underlying maladaptive chronic pain (pain that persists for greater than 3 months) is even less clear. Chronic pain affects up to one-fifth of US adults, and its complexity is attributed to a confluence of physical, emotional, and cognitive factors that contribute to suffering and disability. The epidemic of chronic pain initially contributed to the rise of the opioid epidemic and continues to plague nearly all fields of clinical medicine. Identifying and validating biomarkers to predict individual risk for chronic pain facilitate a precision medicine approach to pain medicine. A new human study using an experimental prolonged pain model by Chowdhury et al may bring us one step closer to the objective prediction of individual pain sensitivity.},
    doi = {10.1001/jamaneurol.2024.4743},
    url = {https://doi.org/10.1001/jamaneurol.2024.4743}
}