@INPROCEEDINGS{fitoz.23,
  	author={Fitoz, E.C. and Alagapan, S. and Waters, A. and Tiruvadi, V. and Veerakumar, A. and Obatusin, M. and Choi, K.S. and Crowell, A. and Riva-Posse, P. and Butera, R. and Mayberg, H. and Rozell, C.J.},
  	booktitle={2023 11th International IEEE/EMBS Conference on Neural Engineering (NER)}, 
  	title={Exploration of Acute Effects of Stimulation Frequency on Subcallosal Cingulate Dynamics in SCC DBS}, 
  	year={2023},
	month = apr,
	address = {Baltomore, MD},
  	abstract = {Deep Brain Stimulation (DBS) of the subcallosal cingulate cortex (SCC) is effective in treating patients with treatment-resistant depression. While the stimulation intensity (voltage, current) is often changed during therapy, the stimulation frequency is often set to be constant at 130 Hz, as the effect of stimulation frequency on SCC dynamics is unclear. The purpose of this study was to examine the acute effects of different stimulation frequencies on local field potentials (LFP) recorded from ten patients who underwent chronic SCC stimulation to treat TRD. In the experiment, short pulse trains of 2 minutes duration and 6V amplitude were used, with frequencies varying monotonically between 10 and 130 Hz. The spectral power change computed for canonical frequency bands (delta, theta, alpha, beta, and gamma) during post stimulation offset. While we did not find a significant effect of stimulation frequency, we observed a difference in responses to acute stimulation in beta and gamma bands, between patients who had undergone chronic stimulation and those who had not. Moreover, we investigated the predictive nature of acute changes in right hemisphere gamma oscillations on treatment outcome. Our results suggest that stimulation frequency may not be significant factor determining outlasting effects of acute stimulation. Furthermore, chronic DBS may contribute to an adaptive process at the local circuit level.}
  }